Flickr ADHD – ADD
For reasons unknown to me, Concerta continues to be the main methylphenidate drug while it would in theory creates more adverse effects than the use of a pure d-methylphenidate formulation like the one used in Focalin. The theory behind that is the same as the theory and facts that makes Dexedrine (D-Amphetamine) more effective that the racemate amphetamine ( 50% L and 50% D-Amphetamine) or to mention an even more drastic example the difference between the L-Methamphetamine in Vicks inhalators and the D-Methamphetamine as in the worldwide epidemics that have shown that there really are drugs potent enough to shut down a crack house, might explain the difference practically.
Simply put it – the D version has the effect, the L version don’t. So why are they using the L-version at all? The formulation of newer brands like Adderall don’t make sense at all since they contain 25% of the L-Amphetamine which will increase the cardiovascular side effects and from a pharmacological point of view, but might do it from a short term commercial patentable perspective. Then we have the commercial benefits against the health of our child’s, and you are welcome. Why shall we not kill a company for that, it is just a company and how else can they learn?
Or is there really a reason to put L-Amphetamine in the D-amphetamine, as exemplified in Adderall? Well then maybe someone have the guts and the science to explain why. -So please come on! Don’t be shy, are there really any benefits for the children in receiving any central stimulating medication with the L-enantiomer, then where is the scientific proof of that? To boil up a smoke screen with some salts and some enantiomeric solutions like in Adderall has make it possible to sell the Amphetamine to a price 10 times higher than the old products and the molecule making the medicine effective are still the same as in 1950.
To put different salts on Amphetamine skeleton can have some logics in it but not to include the enatiomere with more cardiovascular side effects, or? To use D/L methylphenidate gives less effect with increased cardiovascular effect compared with pure D-Methylphenidate so why is it still used?
-Is there any science in it?
ADHD To medicate or not with Dr Russel Barkley
To medicate ok, but then we want to have the most efficient medicine with the least side effects right?
Filed under: ADHD, Science Tagged: ADHD Medicine, ADHD Meds, Concerta, D/L-Amphetamine, D/L-Methylphenidate, Focalin, Methyphenidate, Ritalin
